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Dr Saloni Sinha earned her Ph.D. under the supervision of Prof. Maneesha S. Inamdar in hematopoiesis and stem cell biology from the Jawaharlal Nehru Centre for Advanced Scientific Research, India in December 2019. During her Ph.D., she undertook an integrated approach for deciphering the conserved role of OCIA domain proteins (Asrij/OCIAD1 and OCIAD2) in blood stem cell homeostasis. Her work identified a new mechanism of wild type p53 regulation that maintains quiescence of bone marrow hematopoietic stem cells and how its dysregulation drives myeloproliferative disorder in asrij knockout mice. Further analysis showed that asrij KO HSCs age prematurely due to aberrant endosomal, mitochondrial and proteasomal activity. This gave new insight into the role of Asrij/OCIAD1 in preventing organelle dysregulation and retarding aging. After completing her Ph.D., she moved to Yale University, USA for a postdoctoral training in immunobiology, where she studied how dysregulation of the unfolded protein response and ER stress in macrophages promotes intestinal inflammation and injury, before joining the Schwartz Lab at Weill Cornell Medicine, USA in April 2021. Dr Sinha is currently working towards understanding the molecular mechanisms underlying homeostasis, inflammation, and aging in the mammalian liver.
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