Chetana Sachidanandan

My lab uses zebrafish as a surrogate to understand the underpinnings of human diseases. Using genetic manipulations such as transgenics, antisense knockdowns and CRISPR-based mutations, we perturb candidate gene function in the zebrafish. We then use these genetically altered zebrafish as models to shed new light on the disease pathophysiology and to discover new chemical and genetic interventions to prevent or alleviate the defects. We are directing our efforts to probing neurodevelopmental disorders such as Dyslexia, Dyscalculia, ADHD, Autism, Intellectual Disability etc.