What happens when evolution reshuffles the genome, but the regulatory instructions that control genes still need to work? A change in genomic neighbourhood can bring regulatory elements into unexpected proximity with genes, creating potential conflicts in gene regulation.

This paper explores how cells deal with these conflicts and how the 3D organization of the genome may provide part of the answer. Rather than simply looking at DNA as a linear sequence, the study takes us into the spatial organization of the genome and asks how changes in its architecture can help preserve regulatory control despite evolutionary rearrangements.

What if moving the pieces changes who can talk to whom?

The Title:Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes

The Who: Sukanya

The What: DBJC

The When: Wednesday, 21st October; 4PM – 5PM

The Where: Chloroplast, 2nd Floor, ELC; or click right here (Log in using Meeting ID: 893 5665 4627; Passcode: 2BEW7K)

The Who Next: Prof. Hiroshi Hamada (Perspective talk)

In the meantime, if you come across exciting papers that you’d like covered at DBJC, please put them up here. This spreadsheet also has the roster, for your reference. You can sign up here. Please write to us if you have questions/comments. We’d appreciate any feedback!